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Image Search Results
Journal: Molecular Pain
Article Title: NMDA Receptor-Dependent Synaptic Depression in Potentiated Synapses of the Anterior Cingulate Cortex of adult Mice
doi: 10.1177/17448069211018045
Figure Lengend Snippet: GluN2C/D-containing NMDA receptors were not involved in synaptic depression after synaptic potentiation. (a) The summarized fEPSP slope plot about the effect of PPDA (GluN2C/D-selective NMDA receptors antagonist, 10 µM) on synaptic depression after potentiation (n = 9 slices/8 mice). (b) Statistical results showed that significant difference was observed between TBS and LFS by comparisons of the last 10 min fEPSP slopes in presence of PPDA (TBS: 130.48 ± 2.80% of the baseline; LFS: 102.98 ± 6.17%). ** p <0.01, paired t -test, compared with TBS. (c) The averaged fEPSP slope plot about the effect of UBP145 (GluN2D-selective NMDA receptors antagonist, 3 µM) on synaptic depression after potentiation (n = 14 slices/11 mice). (d) Statistical results showed that the averaged fEPSP slope after TBS was higher than that of LFS (TBS: 123.94 ± 1.77%; LFS: 114.43 ± 3.56% of the baseline; * p <0.05, paired t -test, compared with TBS). Error bars indicated SEM.
Article Snippet: Selective competitive NMDA receptor antagonist AP-5 (Cat. No. HB0225) and
Techniques: